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While initially benign, these lesions can become malignant over time. Oral Submucous Fibrosis A chronic, progressive condition characterized by the stiffening of the oral mucosa, leading to difficulty in opening the mouth

In 2002, the company was acquired by Reynolds American and is now a subsidiary and independent, even though 42% of Reynolds American is owned by British American Tobacco

However, differences in cancer risk by age group should be carefully considered due to the insufficient follow-up to determine smoking behavior and incidence of cancers

It also leads to changes to mucosa and oral cancer, esophageal cancer and dry socket