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Authorities say smoking causes some 80,000 deaths a year in the U.K, and remains the number one preventable cause of death, disability and poor health.

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The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling: Adverse reactions commonly reported by COC users are: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to the rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice