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Cigarette smoke extract (CSE) impairs bone remodeling mediated by the NFB pathway Studies of adverse effects of cigarette smoke exposure on bone have been made challenging by the properties of cigarette smoke, which is composed of over 4,000 different chemicals, including 43 known carcinogenic compounds and 400 other toxins

Fit of Poisson models was confirmed using Pearson goodness-of-fit test

this is equivalent to an estimated increase of 6.3 MACE events per 1,000 patient-years of exposure

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