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Endothelial cells exposed to caramel, cinnamon and vanilla flavors showed an increased uptake of low-density lipoproteins and lipids, which increases blood vessel inflammation and injury as well as a decreased ability for wound healing

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Breathing in this smoke exposes the oesophagus to these substances, leading to irritation and inflammation

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At the end of the day, everyone knows that if they post a photo of themselves smoking, their mother will send them a message or post a snarky comment.