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Fifty e-cigarette puffs was selected as an optimal controlled dose as it approximated the dose of nicotine delivered by the cigarette used in the study (~0.8 mg) based on machine yields of the e-cigarettes determined previously using a standardized Canadian Intense puffing protocol [20, 21]

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In practice, you notice the difference above all in three points: the draw becomes cooler, softer, and the mouthpiece discolours more slowly

Nicotine also stimulates the release of norepinephrine, another neurotransmitter that plays a role in alertness and attention

This efficiency contributes to a satisfying user experience