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Acknowledgements This study was supported by the Bio & Medical Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (2017M3A9E8023001 and 2017M3A9E8023016), grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant Number: HI18C0331), and grant (BCRI18024) of Chonnam National University Hospital Biomedical Research Institute