At the time, there was no direct evidence of harm from vaping and the limited biological studies of nicotine gave a mixed picture clear potential for addiction, and activation of the cardiovascular system, but fewer of the toxic effects of the carcinogens and inflammation-producing components of tobacco tar
Among men, the pooled relative risk for coronary heart disease was 1.48 for smoking one cigarette per day and 2.04 for 20 cigarettes per day, using all studies, but 1.74 and 2.27 among studies in which the relative risk had been adjusted for multiple confounders
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Herbert Gilbert filed a patent in 1963 for a smokeless non-tobacco cigarette device
The main claim is that someone can use nicotine sources similar to caffeine, but this is a fools errand according to Jennifer Folkenroth, American Lung Associations Sr