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Current guidelines that make no distinction among different subsets of the population may not be the most effective use of efforts to control death from tobacco-related diseases like lung cancer, Holford said, noting that additional studies are needed to determine whether a sufficient number of African Americans are screened under current guidelines or if changes to current policy are necessary

Methods/design Study design This clinical trial will use a double-blind, placebo-controlled, dose escalation design, with random assignment of participants to an experimental (group A) and a control condition (group B) for 10 weeks after failure to achieve abstinence during an open-label run-in period of approximately 2 weeks using a 21-mg nicotine patch daily

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