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Furthermore, it was reported that short-term hookah use (both tobacco-based and tobacco-free products) disrupts the autonomic nervous system regulation on the cardiac cycle, thereby causing a reduction in HRvariability, whichin turnmight aggravate the risk of coronary artery disease development [18]

The term reflects both epidemiological sequential patterns and, for nicotine specifically, a demonstrable molecular mechanism of cross-sensitization verified through peer-reviewed experimental research

Subramaniam RP, Asgharian B, Freijer JI, Miller FJ, Anjilvel S

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