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Prior to this, vitamin E (800 IU daily) has shown histologic benefit in non-diabetic, biopsy-proven NASH patients in clinical trials, though long-term safety concerns exist including potential increased risks of hemorrhagic stroke and prostate cancer in men

Substances with strong anti-inflammatory activity were further tested for in vitro TNF- production

Trandel-Hayse et al., 2025)

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Depletion of the brain antioxidant glutathione (GSH) may be important in OS-mediated neurodegeneration, though studies of post-mortem brain GSH changes in AD have been inconclusive