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importantly, cumulative exposure (measured in pack-years) was strongly associated with fibrosis severity, with each additional pack-year tripling the likelihood of advanced fibrosis (adjusted OR per pack-year: 3.2

Zyn avoids inhalation risks, but both have potential health concerns

Quitting chewing tobacco can be challenging for a variety of reasons

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Since this product was first developed in 2004 in China as a tobacco cessation device, it has grown rapidly so that in 2013 the estimated market is about 1.5 billion as compared to 100 billion for tobacco sales