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Introducing steric blockade has proven a successful strategy to increase the stability of a peptide in vivo but typically this has been at the expense of potency, as for instance a 48-fold difference at human GLP-1R in transfected CHO cells between Ab#2_DSB#1 and the same molecule without the disulphide bridge (Ab#2_EX4)

Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans

Track when symptoms occur in your cycle to distinguish cyclical from non-cyclical patterns

Vitamin B6 acts as a "chaperone" for magnesium, helping to ferry the mineral into the cells where it can do its work

A deficiency can lead to twitchy muscles and nighttime leg cramps