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Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

Oral administration of PF-06882961 shows evidence of glucose-lowering in healthy human study participants PF-06882961 was selected as a candidate for clinical studies based on its in vitro and in vivo pharmacologic and disposition profile, including potent agonism of the GLP-1R, preclinical disposition attributes (e.g., low metabolic CL int in human hepatocytes), good safety margins versus the hERG channel (IC 50 = 4.3 M, Table S4) and broad panel screening (Table S8), and selectivity versus related class B GPCRs (Table S9)

Serum carnitine concentrations reflect less than 0.5% of the total body carnitine pool of which 98% is represented by the muscle mass, the remaining 1.5% being distributed between the different organ systems and blood cells 16

Xiao B-H, Shi M, Chen H, Cui S, Wu Y, Gao X-H, et al