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Despite its small size, it is remarkably lipophilic for a peptide meaning it crosses the blood-brain barrier with relative ease

Zhong W, Wu A, Berglund K, Gu X, Jiang MQ, Talati J, et al

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases

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