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For humans, acute toxicity estimates (ATE) were 3.3 mg per kg body weight for acute oral toxicity and 0.25 mg/L for acute inhalation toxicity 65

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In addition, PG with nicotine caused increased macrophage and CD4 + /CD8 + T-lymphocytes cell counts in BALF compared to air control, but these effects were ameliorated when animals were sub-chronically exposed to PG alone [42]