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5.1 Screening potential Recently, DNA methylation status has been suggested for a triage strategy for HPV cases and for atypical squamous cells of undetermined significance (ASCUS) cases ( Previous investigations suggested that methylation of the CADM1 and MAL genes may serve as effective biomarkers for identifying cervical intraepithelial neoplasia grades 2 and 3 (CIN2/3), and demonstrating higher sensitivity than traditional cytology-based triage methods (Verhoef et al., 2015)

This indicates that such long-term health consequences are not confined to one generation, but also continued to impair the health of a future generation