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These two factors together mean that more nicotine is delivered to the brain faster from vaping than from smoking a cigarette

Oxidative stress induces DNA, protein, and lipid damage during embryogenesis Intrinsic ROS generation is tightly regulated to prevent overproduction and subsequent oxidative damage

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There's also some evidence that people who use electronic cigarettes to quit have a higher relapse rate as well. The studies which show electronic cigarettes are effective also all pair it with intensive behavioural interventions and counselling, a point which Prof Edwards says further complicates things