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Higher nicotine concentration in e-cig liquid, as well as use of advanced second-generation e-cigs, which deliver nicotine more efficiently than earlier "cigalikes," predicted dependence

on the other hand, elevated levels of xanthine oxidase may lead to increased production of reactive oxygen species, which in turn increases lipid peroxidation reactions, aggravating the great damage to cells increasing cell turnover thus leading to increased purine catabolism and thus increased uric acid production 25

amid "regulatory complexity" and "uncertainty" surrounding the industry, the company said in an internal memo Friday

"Obscured by the smoke"