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Part of the problem was the inclusion criteria of needing witnessed emesis, the exclusion due to IV ondansetron being given as a standing medical order for all-cause emesis before clinical assessment, lack of research personnel (Nerdy point#1) and a belief by some clinicians that their practice approach was superior to the study protocol

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Introduction to mediation, moderation, and conditional process analysis: A regression-based approach

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doi:10.1007/BF01054525