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Young people who vape are more likely to smoke conventional cigarettes in the future

Indeed, when nicotine is administered concurrently with a CYP2A6 inhibitor of unknown strength, the substrate metabolism will be reduced, resulting in increasing serum concentrations and heightened risk, incidence, and/or severity of ADRs

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This can vary widely, so it's often more practical to monitor how satisfied you feel rather than strictly counting puffs