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Notably, the oral microbiome composition in oral cancer patients was not driven by smokeless tobacco consumption status, whereas its variation was observed according to the sample site (tumor and contralateral healthy site)

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Therefore, large-scale and longitudinal metagenomic studies on cohorts from different geographical regions are much needed to understand the underlying mechanisms of microbiome-associated dysbiosis and carcinogenicity

Since the IOM report, real-world evaluations of the impact of increasing the tobacco purchase age from 18 to 21 have been published

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