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Adjusting dose or administration time usually resolves this

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Mol Neurobiol 56(6):38823896 Wang Z, Roberts AB, Buffa JA et al (2015) Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

In fact, dehydration can weaken your skin barrier, making your skin prone to redness, sensitivity and breakouts