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Endothelial dysfunction can be improved by appropriate pharmacotherapy [8,9,10,11], replacement therapy [12, 13], and lifestyle modifications including aerobic exercise [14, 15], body weight reduction [16], decrease in salt intake [17] and smoking cessation [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]

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Internalizing behaviors are inward-facing, such as anxiety, depression, or social withdrawal

These include managing specific types of chronic pain, reducing nausea and vomiting associated with chemotherapy and increasing appetite and weight gain in those with HIV/AIDS