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For the purpose of randomization following the 2-week run-in with the 21-mg nicotine patch, quit status will be determined by participants self-reported 7-day point prevalence abstinence (PPA), defined as no smoking, not even a puff, for the past 7 days
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High levels of nicotine found in cigarettes can decrease the effectiveness of insulin treatments, forcing those who smoke to compensate with higher doses of insulin, usually administered by syringe or insulin pen
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