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This review examines a broad spectrum of endogenous peptidereceptor systems that regulate metabolism, appetite, bonemusclefat crosstalk, neuroendocrine function, immune modulation, and tissue repair, yet lack approved therapeutic analogs

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Front Pharmacol 13:791376 Hermans J, Bierma-Zeinstra S, Bos PK, Niesten DD, Verhaar JA, Reijman M (2019) The effectiveness of high molecular weight hyaluronic acid for knee osteoarthritis in patients in the working age: a randomised controlled trial

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