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A 2022 systematic review and meta-analysis of 18 randomized trials including 883 hypothyroid patients and evaluating outcomes like depression, fatigue, pain, anxiety, and anger, found no statistically significant advantage of combined LT4+LT3 therapy over LT4 monotherapy on any of these psychological endpoints (42)

Yes, 1,000 mcg is a standard supplemental dose of B12

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265,266 Regarding functional MRI, recent studies have revealed that cerebral functional abnormalities are not limited to specific brain regions in patients with MDD