Repeated use can cause dependence
Reading the writing on the wall and what it may signify, telemarketing companies, pharmacies, and other stakeholders selling GLP-1 products that are not FDA approved should consider this change in tone and action from both FDA and manufacturers in planning for the future, including in preparing to defend ongoing GLP-1 compounding or potentially realigning their compounding capacity for future markets
For the DHT mechanism deep dive, see does GHK-Cu block DHT
Emani R, Alam C, Pekkala S, Zafar S, Emani MR, Hanninen A (2015) Peritoneal cavity is a route for gut-derived microbial signals to promote autoimmunity in non-obese diabetic mice
That does not make the symptom more or less serious by itself, but it does add context when clinicians are deciding whether ketones may be involved