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Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging

16,18 Early concerns about pancreatic safety arose from reports of pancreatitis in animal studies with the use of sitagliptin, clinical reports of humans treated with exenatide and the detection of preneoplastic pancreatic ductal lesions in animals treated with GLP-1 receptor agonists

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[21] This can present a problem when the level of our chemical exposure exceeds the ability of these liver enzymes to detoxify them, resulting in higher levels of circulating (unconverted) toxic metabolites, further contributing to an overload of these liver detoxification pathways

Juraschek SP, Miller ER III, Gelber AC