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Exemplifying this potential, nipocalimab has been shown to potently reduce the level of pre-existing neutralizing Abs against adeno-associated virus vectors in NHPs with moderate Ab titers, which improved vector transduction efficacy to target tissues to close to that observed in Ab-negative nave control animals [360]
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& Sharma, J
After blocking in 5% skimmed milk powder for 2 hours at room temperature, the samples were incubated overnight at 4C with primary antibodies, including ERK1/2 (#9102), p-ERK1/2 (#9101), JNK1/2 (#9252), p-JNK (#9251), p38 MAPK (#9212), and p-p38 MAPK (#9211), which were obtained from Cell Signaling Technology (Beverly, MA, USA), as well as VEGF-a (sc-7269) and Tubulin (sc-8035), which were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA)
C., Garrett, T
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