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However, this delay can also lead to gastrointestinal (GI) side effects like nausea, abdominal pain, heartburn or acid reflux, constipation, and diarrhea

It also explains why patients using semaglutide often report not just eating less but genuinely wanting less food a qualitatively different experience from dieting without pharmacological support

Patients with a history of gallbladder problems may require additional monitoring during treatment and dose adjustment

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rather, it reflects a highly integrated process involving olfaction, oral somatosensation, and interoceptive state ( Viewed together, peripheral taste pathways may contribute to GLP-1RA-associated effects, but they are unlikely to account on their own for the broader and more systematic changes observed in eating experience and behaviour