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Tirzepatide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and should not be used during pregnancy due to potential fetal harm

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Gut 61 , 970976 (2012)

The FDA usually relies on clinical trials when it is looking at adding a substance to the 503A bulks list, which determines what ingredients compounding pharmacies can use in mixing drugs