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Clinical trials confirmed no effect on serum IGF-1, no negative impact on carbohydrate metabolism, and excellent tolerability with safety profile indistinguishable from placebo
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[30] For example, cyanocobalamin can be converted to its analog cobalamins via reduction to B 12s , followed by the addition of the corresponding alkyl halides, acyl halides, alkene or alkyne
25 Folate Duration of therapy Patients with pernicious anemia require lifelong therapy, while patients with malabsorption require treatment until underlying condition or diet is corrected
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