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Air samples were passed through a 44-mm glass fiber filter (Borgwaldt KC, Hamburg, Germany) at an air sampling flow rate of 2 L/min

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Abbreviations AUC: Area under the curve CMS: Cigarette Management System CO: Carbon monoxide FDA: Food and Drug Administration IRB: Institutional review board ITP: Investigational Tobacco Product NRT: Nicotine replacement therapy REDCap: Research Electronic Data Capture RNC: Reduced nicotine content SES: Socioeconomic status TCA: Family Smoking Prevention and Tobacco Control Act TCORS: Tobacco Center of Regulatory Science UNC: Usual nicotine content References Benowitz NL, Henningfield JE